Antibiotic of the streptothricine family, effective against a broad spectrum of viruses, bacteria and fungi. Used as selection antibiotic for genetically modified bacteria, yeasts, filamentous fungi, protozoa and plants.Nourseothricin inhibits biosynthesis and induces miscoding. Resistance is mediated by the sat1 encoded N-acetyltransferase, which inactivates nourseothricin by acetylation of the β-amino group of the β-lysin.

Streptothricine F: n=1 (MW 599.59), Streptothricine D: n=3 (MW 857.95)

Recommendation: One package Nourseothricin should be solubilized in whole and the stock solution should be frozen in aliquots. By removing the overlaying argon during weighing, the stability of the lyophilsate is reduced.