Glucocorticoid receptor rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20734-50, ES20734-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking pat

Alternate Name: NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1

Source: Rabbit

Applications: WB

Dilution: WB: 1:1000-3000

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein of Glucocorticoid receptor

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Observed Band (KD): 80-97kD

Human Gene ID: 2908

Human SWISS Prot NO: P04150

Subcellular Location: [Isoform Alpha]: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity).; [Isoform Beta]: Nucleus. Cytoplasm. Expressed predominantly in the nucleus with some expression also detected in the cytoplasm.; [Isoform Alpha-B]: Nucleus. Cytoplasm. After ligand activation, translocates from the cytoplasm to the nucleus.

Research Use Only